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Title: Evaluation of hypothermia for anaesthesia in neonatal rats, implications for animal welfare and experimental data
Author: Rhodes, Shelley
ISNI:       0000 0004 2669 3757
Awarding Body: University of Newcastle Upon Tyne
Current Institution: University of Newcastle upon Tyne
Date of Award: 2009
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Hypothermia is the most widely used technique of anaesthesia for neonatal rats and mice up to 10-14 days of age in research facilities worldwide. This technique has been used for many years and has been shown to be safe and effective. However, controversy exists as to whether it is humane. It is supposed that during hypothermia, the degree of suppression of the peripheral and central nervous system is sufficient to prevent the animal experiencing pain. However, this raises the concern that peripheral nerves that control movement are affected before the nerves that transmit sensation.This would mean that the animal is immobilised without analgesia in a similar way as using neuromuscular blocking agents without using concurrent anaesthesia. These results suggest that hypothermic anaesthesia in neonates should be replaced by other anaesthetic techniques particularly for recovery surgery.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available