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Title: Studies of protein binding to the three prime untranslated region (3'UTR) of glucose transporter mRNA
Author: Pedder, Christopher
ISNI:       0000 0004 2669 3693
Awarding Body: University of Newcastle Upon Tyne
Current Institution: University of Newcastle upon Tyne
Date of Award: 2009
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As part of gene exptession within the cell, the regulation of mRNA stability, translation and transport is facilitated by trans-acting proteins that bind to cis-acting signals, present mainly within the 3'UTR. These processes can all contribute to the localisation of a transcript, vital in the development of many eukaryotic cell types, including oocytes, fibroblasts and epithelial cells. The majority of mRNA locahsation studies have concerned mRNAs encoding cytoplasmic proteins. Recent studies, however, have also shown that mRNAs encoding membrane and secreted proteins can also be localised. Recent evidence indicates that these mRNAs may be associated with specific sub-regions of the endoplasmic reticulum (ER) as means of controlling the translation of membrane/secreted proteins, and therefore refining localisation of the mRNA targeting to specific sub-regions of the ER is believed to involve a process independent of signal peptide translation and recognition, and thought to be govemed by signals in the RNA, a number of which have been found in the 3'\3TR. therefore strongly implicates IMPl in the post transcriptional processing of the SGLTl mRNA and possibly is apical locahsation in enterocytes.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available