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Title: Defining genes that regulate the differentiation status of neuroblastoma cell lines
Author: Sung, Pei-Ju
ISNI:       0000 0004 2669 3597
Awarding Body: University of Newcastle Upon Tyne
Current Institution: University of Newcastle upon Tyne
Date of Award: 2009
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Defects in differenfiafion are one of the major events presented in highly malignant leuroblastoma tumours. Evidence suggests differentiated neuroblastomas are Lssociated with improved patient outcome, but little is known regarding the molecular regulafion of differenfiation in vitro and in vivo. Although differentiation can be induced by alternative treatments, we hypothesise that there are some genes in common that become altered and a subset of these regulate the differentiation process in neuroblastoma cells. In conclusion, a set of candidate genes were identified to be involved in the regulation of neuroblastoma cell differentiation.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available