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Title: Nanoscale structure of membrane protein arrays
Author: Pierre Le Brun, Anton
ISNI:       0000 0004 2669 3423
Awarding Body: University of Newcastle Upon Tyne
Current Institution: University of Newcastle upon Tyne
Date of Award: 2009
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Electron microscopy and atomic force microscopy can provide structural information on the surface of a membrane and spectroscopic techniques tell us about the structure and dynamics i integral membrane proteins. However none of these techniques relate to what is happenmg in the 5 to 6 nm thick layer under the surface of the membrane. Only reflection methods can provide information about the distribution of materials on the axis perpendicular to the membrane surface (the z-axis). Neutron scattering can discriminate between hydrogen and its isotope deuterium, making neutron reflection a powerfiil tool for dissecting how lipid, protein and solvent relate to one another along the z-axis and providing a method in which certain components can be highhghted or made invisible by choosing the correct solvent contrast. This data helped in the design of new antibody-binding biosensors that have a greater efficiency for antibody binding and greater stability for transportation.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available