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Title: Formation of CDP-ribitol for teichoic acid biosynthesis in Streptococcus pneumoniae
Author: Baur, Stefanie Susanne
ISNI:       0000 0004 2669 3343
Awarding Body: University of Newcastle Upon Tyne
Current Institution: University of Newcastle upon Tyne
Date of Award: 2009
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The Gram-positive bacterium Streptococcus pneumoniae is a major human pathogen causing pneumoniae, blood-stream infections and meningitis. Many of the interactions of this bacterium in humans are mediated by components of the pneumococcal cell wall. The cell wall has a complex structure and is made of a thick peptidoglycan with a covalently linked wall teichoic acid (WTA), cell surface proteins and capsular polysaccharides. In addition, there are surface-exposed, lipid-linked components of the cell envelope such as lipoteichoic acid (LTA) and lipoproteins. The repeating units of WTA and LTA have an identical chemical structure, and both polymers are substituted with phosphorylcholine (PCho) residues.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available