Nasopharyngeal carcinoma, NPC, is a very commonly occurring cancer in Hong Kong. The physiotherapy service provision for NPC patients in Hong Kong has to date been unstructured and the musculoskeletal complications post radiotherapy are often neglected. This study aimed to develop an evidence-based treatment protocol grounded in patients' perspectives and experiences, and to evaluate the effect of a pilot multimodal treatment programme for patients with NPC following irradiation. The context for establishing the tenets underlying a multimodal treatment strategy addressing the multidimensional issues of patients was first set. A qualitative methodological approach was utilised to help gain an emic view of the lived experiences of patients receiving physiotherapy in their rehabilitation journey. The knowledge gained through the qualitative study was used to formulate a grounded multimodal treatment package which comprised a patient pre-treatment symptom-screening questionnaire, an integrated clinical checklist, and an education package to facilitate patient empowerment.