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Title: NG2-glia : a synaptic element with neural stem cell potential
Author: Wigley, Rebekah Josephine
ISNI:       0000 0004 2672 3282
Awarding Body: University of Portsmouth
Current Institution: University of Portsmouth
Date of Award: 2009
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NG2-glia, identified by their expression of the NG2 chondroitin sulphate proteoglycan (CSPG), represent a fifth glial cell population in the central nervous system (CNS). NG2-glia were originally considered to be oligodendrocyte progenitor cells (OPCs), but they have properties and distribution in the adult that is distinct from OPCs. NG2-glia have been shown to form contacts with axons at nodes of Ranvier in white matter and to respond to synaptically released glutamate in grey matter. Furthermore, NG2-glia are known to give rise to oligodendrocytes after demyelination in vivo and to form neurons and astrocytes in vitro. However, the function of NG2-glia remains largely undefined. Therefore, the aim of this thesis was to define the interrelations of NG2-glia with other elements in the CNS and test the hypothesis that they are multipotent neural stem cells (NSCs).
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available