Incidence of neoplasm increases with age. However age-related differences in similar tumours are not well characterised and the biological reasons for the potential differences remain unknown. These are thought to include proliferation, apoptosis, cell survival (telomere maintenance/telomerase expression), chromosomal and genomic instability This increase in expectations of histological reporting has obviously impacted on the workload of pathologists. Consequently there is a move to delegate appropriate parts of this work to suitably trained and qualified senior scientists. This study aims to assess the differences between tumours of the young (<50) compared with those of the old (>70) and use the models derived from the morphological and biological assessments to add to the prognosis of tumours in the mid age group (50 - 70).