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Title: Antibody-enzyme conjugates for cancer therapy
Author: Ahmed, Sarah
Awarding Body: University of London
Current Institution: Imperial College London
Date of Award: 2008
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Advances in cancer therapy have led to the exploitation of the biological differences between cancer and normal cells. A popular approach is to attach a targeting moiety such as an antibody to a toxin or toxic enzyme in order to specifically locate and kill cancer cells only. However, many immunotoxins have fared poorly in their clinical trials, having shown to elicit immunogenic responses and toxicity in the patient. This problem is commonly attributed to the non-human sources of the toxins and enzymes being delivered. Targeting cytotoxic agents from human sources is therefore a prospective solution. Accordingly, this project aims to develop an immunoconjugate using mammalian or 'mammalian-like' enzymes for the treatment of epithelial cancers over-expressing the MUCl tumour antigen.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available