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Title: An investigation into the cis-platin resistance exhibited by MMR-defective S. Cerevisiae cells
Author: Clyne, Melanie Jane
ISNI:       0000 0004 2674 004X
Awarding Body: Sussex University
Current Institution: University of Sussex
Date of Award: 2009
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The primary function of the mismatch repair (MMR) pathway is to protect cells against the mutagenic and cytotoxic effects of mismatches incorporated by polymerases during replication. Accordingly, mutations in the MMR genes are commonly identified in patients with hereditary non-polyposis colon cancer (HNPCC) and somatic colorectal cancers. MMR function is of particular importance in cells exposed to DNA-damaging agents, as aberrant processing of damaged bases and erroneous bypass of bulky lesions increase the tendency for mismatch incorporation. The precise role of the MMR proteins in the processing of CDDP-induced DNA damage is, however, poorly understood.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available