Chitosan is a natural polysaccharide produced commercially from chitin by partial deacetylation. It consists of glucosamine and Al-acetyl glucosamine units chained through glycosidic bonds. Due to the biocompatible and mucoadhesive profile it presents, it has attracted considerable attention for potential uses in pharmaceutics. However, the limited solubility of chitosan only in acidic solutions constrains some of its possible uses in biological applications. Thus, the synthesis of chitosan derivatives with broader solubility and increased functionality has been considered as a strategy to extend chitosan uses.