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Title: Catalytic asymmetric synthesis of pyrrolidine carboxylic acids via tandem heck reaction [2,3]-sigmatropic rearrangement
Author: Tran, Fanny
ISNI:       0000 0004 2673 0335
Awarding Body: Reading University
Current Institution: University of Reading
Date of Award: 2009
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Kainoid amino acids are natural biological active pyrrolidine dicarboxylic acids with potent neuroexcitatory activity as well as insecticidal and anthelmintic properties. They possess 3 stereogenic centres, which represent considerable challenges for synthetic chemists. We speculated that a tandem asymmetric Heck arylation reaction and [2,3] sigmatropic rearrangement would provide a quick and efficient way to access these pharmacological active molecules.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available