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Title: Photochemical investigation of antibacterial fluoroquinolone drugs
Author: Carton, Fernando Lorenzo
ISNI:       0000 0004 2673 0247
Awarding Body: Manchester Metropolitan University
Current Institution: Manchester Metropolitan University
Date of Award: 2009
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The primary photophysical properties of several antibiotic drugs of the fluoroquinolone class have been studied in order to understand better and rationalize the mechanisms leading to phototoxicity due to these drugs. The light absorption and emission properties of various fluoroquinolones have been characterized and, in most cases, they were found to be dependant on medium conditions such as pH and buffer content. Fluoroquinolones have been found capable of binding to DNA, affecting their emission from the excited state. Light-induced production of excited species by FQs and their subsequent reactivity are thus influenced by the characteristics of the medium. Finally, an unprecedented behaviour has been found for the triplet state of fluoroquinolones ciprofloxacin, sarafloxacin, enoxacin norfloxacin when it is formed in the presence of certain inorganic salts commonly used as buffers. The triplet state formed at the end of the excitation pulse reacts with anions such as phosphate and bicarbonate to form another triplet state of lower energy. This previously unreported effect has implications in the photo toxic potential of fluoroquinolones in cellular environments.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available