Neutrophils play a crucial role in the acute immune response. Inflammatory stimuli recruit neutrophils into the tissues. Post-migratory neutrophils may then engage in pathogen killing and phagocytosis. Oedema-formation is associated with neutrophil transmigration, although evidence indicates that these are mechanistically distinct phenomena. Leukocyte-driven oedema is a feature of many inflammatory diseases including asthma, rheumatoid arthritis, and Crohn's disease, the mechanisms underlying neutrophil-mediated oedema are unclear.