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Title: Increased invasive behaviour of cutaneous squamous cell carcinoma with knock-down of Type VII collagen
Author: Martins, Vera Lisa Coelho
ISNI:       0000 0004 2670 5498
Awarding Body: Queen Mary, University of London
Current Institution: Queen Mary, University of London
Date of Award: 2008
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Type Vll collagen (ColVII) is the main component of anchoring fibrils, structures within the lamina densa of the basement membrane responsible for dermal-epidermal adherence in skin. Mutations in the human ColVll gene, C0L7A1, cause the severe inherited blistering disorder recessive dystrophic epidermolysis bullosa (RDEB) affecting skin and mucosae associated with a greatly increased risk of skin cancer. The aim of this study was to investigate the effect of loss of ColVII on cutaneous SCC behaviour using RNAi.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available