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Title: Investigation of the role of the 5’-3’ exoribonuclease pacman in Drosophila wound healing
Author: Sullivan, Melanie Jane
ISNI:       0000 0004 2675 2737
Awarding Body: University of Brighton
Current Institution: University of Brighton
Date of Award: 2008
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The Drosophila gene pacman encodes a 5’-3’ exoribonuclease, which is involved in RNA degradation. pacman mutants were created by P-element excision. These mutants have phenotypes including dull and blistered wings, kinked legs and thoracic closure defects. Also, pacman mutant embryos show a dorsal closure defect. The thorax and dorsal closure phenotypes in pacman mutants closely resemble those observed in flies mutant for genes of the highly conserved JNK signalling pathway, for example hemipterous (JNKK), basket (JNK) and kayak (Dfos). These similarities suggest pacman may be involved in regulating the JNK pathway. The JNK signalling pathway is known to regulate morphological processes such as dorsal closure during Drosophila development and wound healing. The phenotypes of our pacman mutants suggest pacman may have a role in these processes possibly through interactions with the JNK signalling pathway.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available
Keywords: A000 Medicine ; A300 Clinical Medicine ; C400 Genetics