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Title: An investigation into the biological effects of lycopene at cellular and molecular level
Author: Elgass, Simone
ISNI:       0000 0004 2670 5041
Current Institution: University of Portsmouth
Date of Award: 2009
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Prostate cancer is the most commonly diagnosed cancer in British men and the second most common cause of cancer mortality, exceeded only by lung cancer. Oxidative stress is known to play a role in cancer and cardiovascular disease, implying a connection between diets low in antioxidants and chronic disease development. Apparently involved in chronic illnesses such as cancer and atherosclerosis, transcription factor Nuclear Factor kappaB (NF-κB) has attracted widespread interest. NF-κB is activated during the inflammatory response. Being a redox sensitive transcription factor, it is also affected by oxidative stress. The factor is ubiquitously expressed in the cytoplasm of all cells, where it regulates expression of genes that control immune system. growth and inflammation.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available