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Title: Procoagulant activity, airway remodelling and inflammation in moderate and severe asthma
Author: Brims, Fraser John Hall
ISNI:       0000 0004 2670 3353
Awarding Body: University of Nottingham
Current Institution: University of Nottingham
Date of Award: 2008
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Asthma is a chronic disease characterised by airway inflammation and remodelling. Inhaled corticosteroids (ICS) are the cornerstone of asthma therapy, and yet many asthmatics remain symptomatic, some with severe manifestations of the disease. The bronchial epithelium produces coagulation factors locally in the absence of plasma exudation. There is evidence in asthma that there is upregulation and stimulation of the external coagulation cascade in the airways, and locally derived factors may be involved.
Supervisor: Shute, Janis Kay ; Chauhan, Anoop Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available