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Title: The chemical modification of the lantibiotic mersacidin
Author: Hagan, Andrew Kevin
ISNI:       0000 0004 2669 7213
Current Institution: University of Manchester
Date of Award: 2009
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Lantibiotics are antibiotic natural products that are synthesised ribosomally and undergo extensive post-translational modification, resulting in multiple thioether bridges and dehydro amino acids in the mature peptide. One such lantibiotic is mersacldin, which is produced by Bacillus sp. and exhibits extremely promising in vitro and in vivo efficacy versus a number of clinically relevant pathogens, most notably methicillin-resistant Staphylococcus aureus. Mersacidin is believed to function by binding to the bacterial cell wall precursor lipid II, thereby preventing its incorporation into the growing peptidoglycan network.
Supervisor: Not available Sponsor: Not available
Qualification Name: Not available Qualification Level: Doctoral
EThOS ID:  DOI: Not available