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Title: Dearomatising cyclisations onto pyridines
Author: Brice, Heloise
ISNI:       0000 0004 2675 1507
Awarding Body: University of Manchester
Current Institution: University of Manchester
Date of Award: 2009
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This thesis details investigations into the dearomatising cyclisation onto pyridines. Studies into the cyclisation of enolate or silyl enol ether nucleophiles onto a pyridine ring are described. Flexible hydrocarbon tethers and tethers incorporating either an oxygen or nitrogen atom were investigated and novel fused 6.5 and 6.6 bicyclic piperidines have been synthesised. A one-pot silyl enol ether or silyl ketene acetal formation and cyclisation procedure has been developed.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available