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Title: Approaches towards the total synthesis of the 20-deoxy bryostatins
Author: Hardy, Simon
ISNI:       0000 0004 2674 9845
Awarding Body: University of Manchester
Current Institution: University of Manchester
Date of Award: 2009
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This thesis describes approaches towards the total synthesis of the 20-deoxy bryostatins. The use of CI9 acyl anion equivalents as a means of forming the C19-C20 bond was investigated, leading to the synthesis of 2-[(2'E,6'Z)-(R)-6'-(2-benzyloxymethoxy-ethyl)-1', 1' -dimethyl-4' -triethylsilyloxy-8' -triisopropylsilyloxyocta-2',6'-dienyl]-[l,3]-dithiane (276), representing the C11-CI9 fragment of the bryostatatins.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available