| Use this URL to cite or link to this record in EThOS: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.496225 |
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| Title: | Approaches towards the total synthesis of the 20-deoxy bryostatins | ||||
| Author: | Hardy, Simon |
ISNI:
0000 0004 2674 9845
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| Awarding Body: | University of Manchester | ||||
| Current Institution: | University of Manchester | ||||
| Date of Award: | 2009 | ||||
| Availability of Full Text: |
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| Abstract: | |||||
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This thesis describes approaches towards the total synthesis of the 20-deoxy bryostatins. The use of CI9 acyl anion equivalents as a means of forming the C19-C20 bond was investigated, leading to the synthesis of 2-[(2'E,6'Z)-(R)-6'-(2-benzyloxymethoxy-ethyl)-1', 1' -dimethyl-4' -triethylsilyloxy-8' -triisopropylsilyloxyocta-2',6'-dienyl]-[l,3]-dithiane (276), representing the C11-CI9 fragment of the bryostatatins.
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| Supervisor: | Not available | Sponsor: | Not available | ||
| Qualification Name: | Thesis (Ph.D.) | Qualification Level: | Doctoral | ||
| EThOS ID: | uk.bl.ethos.496225 | DOI: | Not available | ||
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