Use this URL to cite or link to this record in EThOS: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.496093 |
![]() |
|||||
Title: | Stereoselective synthesis of (-)-galanthamine and lupin-type alkaloids | ||||
Author: | Miller, Iain Robert |
ISNI:
0000 0004 2674 2715
|
|||
Awarding Body: | University of Southampton | ||||
Current Institution: | University of Southampton | ||||
Date of Award: | 2008 | ||||
Availability of Full Text: |
|
||||
Abstract: | |||||
A new asymmetric synthetic route to (-)-galanthamine (1.01), a potent Amaryllidaceae alkaloid used in the symptomatic treatment of early on-set Alztheimer's disease (AD), was successfully developed with complete stereocontrol. Key to achieving high chemo-and stereo-selectivity in this approach was the use of transition metal (IM) mediated reactions, in the form of an enyne RCM; a Heck coupling and a titanium based asymmetric allylation. Additionally, application of an asymmetric imino-aldol reaction resulted in the short total synthesis of two Lupin-type alkaloids, tashiromine (3.01) and epilupinine (3.02).
|
|||||
Supervisor: | Not available | Sponsor: | Not available | ||
Qualification Name: | Thesis (Ph.D.) | Qualification Level: | Doctoral | ||
EThOS ID: | uk.bl.ethos.496093 | DOI: | Not available | ||
Share: |