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Title: The baculovirus P10 protein; exploring an enigma
Author: Carpentier, David Cyriel Jermain
ISNI:       0000 0004 2673 7270
Current Institution: Oxford Brookes University
Date of Award: 2008
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After over 30 years of research the role of the baculovirus P10 protein during infection remains a mystery. Believed to be non-essential during infection both in cell culture and in its natural caterpillar host the tiny P10 protein of Autographa californica multiple nucleopolyhedrovirus (AcMNPV) has been associated with a number of intracellular structures and functions. Roles in the formation and release of the baculovirus occlusion bodies have been suggested. This thesis describes a number of studies aimed at further elucidating the role and function of the P10 protein A screen of all available ; baculovirus genome sequences revealed that P10 is evolutionarily conserved within the Alphabaculoviruses. Bioinformatics of all identified P10 homologues revealed an overall structural conservation and a high degree of sequence conservation within the N-terminal 14- amino acids. A number of putative modification sites have been identified thought to play an important role in controlling P10 function.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available