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Title: Luminescent lanthanide complexes for cellular applications
Author: Poole, Robert
ISNI:       0000 0004 2671 9865
Awarding Body: Durham University
Current Institution: Durham University
Date of Award: 2006
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The tetraazatriphenylene chromophore, dpqC, efficiently sensitises europium(III) and terbiiim(lll) emission. It has been incorporated into a series of ligands, based on the :yclen macrocycle, which saturate the coordination sphere of the metal ion and lead to complexes that exhibit high luminescent quantum yields in aerated aqueous media of the order of 15 - 50 %, with long emission hfetimes of the order of milliseconds.The complexes have been shown to be taken up by a number of eukaryotic cell lines and are amenable to time resolved fluorescence microscopy. By relating the structure of the complexes to their uptake and locahsation profiles, it should be possible to design complexes for specific intracellular applications, for example, as probes or components in biological assays.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available