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Title: Descending control of nociception : a role for the cyclooxygenase pathway in the periaqueducatal grey
Author: Leith, Jessica Lianne
ISNI:       0000 0004 2671 5346
Current Institution: University of Bristol
Date of Award: 2008
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The midbrain periaqueductal grey (PAG) has been extensively studied with respect to descending control of nociception and is classically viewed as a source of descending inhibition, resulting in antinociception at the level of the spinal cord. However, recent studies suggest that facilitation can also be evoked from the PAG and descending facilitation from brainstem sites is hypothesised to contribute to the generation and maintenance of chronic pain. Recent work from this laboratory has demonstrated that descending control from the PAG discriminates between spinal processing of A- and C-nociceptive inputs. This has important consequences given the different roles of A- and C- nociceptors in physiological and pathophysiological pain.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available