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Title: The roles of presenilin-1 and proNGF in the cholinergic theory of Alzheimer's disease
Author: Hatchett, Caroline Sara
ISNI:       0000 0004 2671 5290
Current Institution: University of Bristol
Date of Award: 2008
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The cholinergic neurons of the basal forebrain are vulnerable in Alzheimer's disease (AD). These neurons require trophic support by nerve growth factor (NGF) and, uniquely in the brain, express both NGF receptors: TrkA and p75NTR. Reduced support by NGF has been associated with neuronal loss and formation of amyloid plaques and neurofibrillary tangles. This study aimed to increase understanding of proNGF trophic signalling via TrkA/p75NTR and its impact on cholinergic survival in sporadic AD.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available