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Title: The role of SOX2 in regulation of pluripotency and early cell fate decision in embryos and embryonic stem cells
Author: Keramari, Maria
ISNI:       0000 0004 2671 1177
Awarding Body: University of Manchester
Current Institution: University of Manchester
Date of Award: 2008
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The transcription factor Sox2 (SRY-related HMG box gene 2) plays a pivotal role in maintaining self-renewal and pluripotency in embryonic stem (ES) cells derived from the inner cell mass (ICM) of the embryo Previously it was shown that Sox2-/- mouse embryos die soon after implantation,' how materna! Sox2" transcripts may mask an eariier phenotype. This study has shown that siRNA knock-down of Sox2 at the 2-cell stage of the preimplantation mouse embryo results in embryo arrest at the morula stage, increased cellular apoptosis and loss of ability to generate the first differentiated tissue in the embryo, the trophectoderm (TE).
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available