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Title: Exploring the immunomodulatory mechanisms of Trichuris muris isolates
Author: D'Elia, Riccardo V.
ISNI:       0000 0004 2671 0721
Awarding Body: University of Manchester
Current Institution: University of Manchester
Date of Award: 2008
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Studies using the gastrointestinal nematode Trichuris muris typically focus on the E (Edinburgh) isolate. However, two other isolates exist: J (Japan) and S (Sobreda). Earlier experiments showed that following infection with the S isolate of T. muris the C57BL/6 mouse was susceptible and the worms survived, whereas the E and J isolates were expelled. The reason for the prolonged survival of the S isolate is unclear. The purpose of this study was to explore the immunological basis of S isolate survival. Overall, these data suggest that the S isolated has evolved immunomodulatory mechanisms to prolong its survival within the C57BL/6 host.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available