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Title: Effects of type 2 diabetes mellitus on cognitive performance, synaptic plasticity and glutamate receptors in Goto–Kakizaki rats
Author: Brierley, Rachel Claire Mary
ISNI:       0000 0004 2670 4276
Current Institution: University of Bristol
Date of Award: 2008
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Jype 2 diabetes (2DM) is linked with cognitive deficits in aged human patients with poor diabetic control. Conflicting evidence exists from studies Into cognitive deficits using streptozotocin (ST Z) induced and spontaneous diabetic models; furthermore, the mechanism for cognitive deficits is unclear. The Goto-Kakizaki (GK) rat, a spontaneous non-obese model of 2DM, was selected to isolate the effects of prolonged hyperglycaemia on brains of aged GK rats using behavioural tasks, electrophysiology and immunochemistry, compared with age-matched Wistar control rats.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available