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Title: Identification and characterisation of novel translational regulators
Author: Burgess , Danielle
ISNI:       0000 0004 2670 089X
Current Institution: University of Manchester
Date of Award: 2008
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The essential guanine nucleotide exchange factor Eukaryotic initiation factor 2B (eIF2B) plays a critical role in the control of gene expression at both a global and gene specific level. eIF2B is known to be regulated in a number of ways, both directly and indirectly (by phosphorylation of eIF2 in response to kinase activity). The aim of this project was to identify and characterise novel eIF2B interacting/regulatory proteins in yeast. 5. We assessed whether loss of other multi-KH domain containing proteins similarly impacted on eIF2B requirement and found that in addition to scpl60A strains two further strains, heklA dndyll032cA, are candidate translationai repressors, whilst the php2A strain has been identified as a positive regulator of eIF2B. In addition to the KH domain family members, 24 additional candidate eIF2B mutant suppressors were identified as regulators of eIF2B activity.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available