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Title: Notch signalling in CD34+ cells in chronic myeloid leukaemia
Author: Al-Jedai, Abdullah H.
ISNI:       0000 0004 2670 0857
Awarding Body: University of Manchester
Current Institution: University of Manchester
Date of Award: 2008
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Notch signalling is critical for haemopoietic stem cell self-renewal and survival. Chronic Myeloid Leukaemia (CML) is a stem cell disease characterised by the presence of the Philadelphia (Ph) chromosome, and subsequent expression of the BCR-ABL oncogene. The well established role for Notch signalling in human T-cell acute lymphoblastic leukaemia (T-ALL) and the reported mteraction between Notch and ABL in different developmental contexts in DrosopMa raise the possibility that Notch signal ing may be dysregulated in CML. Therefore, this project aims to investigate whether Notch signalling is.altered in CML and to study possible crosstalk between Notch signaliing pathway and BCR-ABL in CML.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available