Global inhibition of protein synthesis is a common response to diverse stress conditions. This allows the protein synthesis machinery to be redirected towards the expression of genes required for protection against the stress. All organisms are exposed to reactive oxygen species (ROS) as by-productsarive metabolism or through exposure to radical-generatmg compounds. An oxidative stress occurs when ROS overwhelm the antioxidant defences of the cell. Here, the regulation of protein synthesis in response to oxidative stress in Saccharomyces cerevisiae was exarnmed after exposure to hydroperoxides.