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Title: Synthesis and evaluation of redox-activated prodrug delivery systems as biological markers
Author: Passmore, Sarah Louise
ISNI:       0000 0004 2670 0427
Awarding Body: University of Manchester
Current Institution: University of Manchester
Date of Award: 2009
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Benzoquinone-based tripartite prodrug delivery systems have been developed to selectively release an active drug under biological conditions. The make-up of the'tripartita delivery asystem is a trigger moiety (quinone) attached to a linker unit (propanoic acid) This is then attached to the active drug via an ester (or amide) link effectively rendering the drug inactive. The aim of this work was to design, synthesise and evaluate a select ct series of prodrug systems and to ascertain whether varying the substituents on the quinone and linker units would enhance the activation of the prodrug and the release of the active ive species following chemical or enzymatic activation.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available