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Title: The role of glutamate-cysteine ligase polymorphisms in chronic obstructive pulmonary disease
Author: Baranes, Tamar Guetta
ISNI:       0000 0004 2670 0080
Current Institution: University of Nottingham
Date of Award: 2006
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GCL is the rate limiting enzyme for the synthesis of glutathione, a molecule that plays an important role in the antioxidant defence of nearly all mammalian cells. GCL is composed of a catalytic and a regulatory subunit, which are encoded by the genes GCLC and GCLM respectively. COPD is a condition characterized by the presence of airflow obstruction and an influx of inflammatory cells into the lungs. Because oxidative stress is believed to contribute to the pathogenesis of COPD, polymorphisms that may affect GCL activity could be associated with a decrease of lung function.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available