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Title: Cannabinoid modulation of neuronal ensemble excitability in the rat brain
Author: Coomber, Ben
ISNI:       0000 0004 0123 3172
Current Institution: University of Nottingham
Date of Award: 2008
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In vivo electrophysiological recordings of neuronal ensemble single-unit and local field potential (LFP) activity were performed in the hippocampus and medial prefrontal cortex (mPFC) of isoflurane-anaesthetised rats to exannine the role of the endogenous cannabinoid system in regulating neuronal excitability. These data suggest that KA-induced hyper-excitability in the rat hippocampus can be suppressed by inhibition of endocannabinoid metabolism (partly via a CB1 receptor-mediated mechanism), the application of a non-selective CB receptor agonist, and in part, by administration of a phytocannabinoid. These observations may have future applications in treating hyper-excitable disorders.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available