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Title: Mechanisms of radiation and antibody-induced cell death in lymphoma
Author: Ivanovs, Andrejs
ISNI:       0000 0004 2668 5239
Current Institution: University of Manchester
Date of Award: 2008
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Radiation and targeted antibody immunotherapy either used alone or combined in radioimmunotherapy are highly effective treatments for some haematological malignancies. However the underlying mechanisms of radio sensitivity and radioresistance in lymphoma and why radioimmunotherapy has such proven clinical efficacy in some patients with chemorefractory disease remain poorly understood. In this work we have first demonstrated the mode of radiation-induced cell death in p53 mutated lymphoma cells. We have shown that endopolyploid cells produced after bypassing DNA damage-induced G2/M arrest have a transient survival advantage that may contribute to radioresistaace of tumours undergoing radiation-induced mitotic catastrophe.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available