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Title: Investigating the role of the Smc5/6 complex when replication folks stall
Author: Irmisch, Anja
ISNI:       0000 0001 3587 0151
Awarding Body: University of Sussex
Current Institution: University of Sussex
Date of Award: 2009
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Structural maintenance of chromosome (Smc) complexes have key functions in chromosome formation and segregation. Eukaryotes possess three essential Smc complexes: cohesin (Smc 1/3) which facilitates sister chromatid cohesion, condensin (Smc2/4), which facilitates chromosome condensation and segregation and Smc5/6, the less well-understood third complex. The Smc5/6 heterodimer interacts with the non-Smc proteins Nse1 to Nse6 to form a functional complex, implicated in DNA repair by homologous recombination (HR) and the segregation of repetitive DNA such as ribosomal DNA repeats. Hypomorphic complex mutants are HR defective and loss of Smc5/6 complex functions results in global chromosome fragmentation and missegregation.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available