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Title: Investigation cytoplasm-to-vacuole targeting pathway genes in Schizosocccharomyces pombe
Author: Lakhani, Ronak
ISNI:       0000 0001 3604 0213
Awarding Body: University of Sussex
Current Institution: University of Sussex
Date of Award: 2009
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The Cvt pathway is an unusual process which transports the two hydrolases aminopeptidase I (Apel) and a-mannosidase I (Amsl) from the cytoplasm directly to the vacuole. So far it has only been described in S. cerevisiae and closely related budding yeasts. Most of the components needed for the Cvt pathway, the Atg proteins. are also required for the autophagy pathway, a degradative system which delivers cytoplasmic constituents to the vacuole in a non-specific manner, induced under conditions such as nutrient starvation. Genes involved in these two pathways play a wide variety of roles in diseases such as cancer, cardiomyopathy, Huntington's and Parkinson's disease as well as the removal of intracellular pathogens and ageing.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available