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Title: Investigations into the cellular and molecular biology of a cytoplasmic dynein mutation which leads to neurodegeneration
Author: Soura, Violetta
ISNI:       0000 0001 3472 3766
Awarding Body: University of Sussex
Current Institution: University of Sussex
Date of Award: 2009
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The aim of this project was to investigate into the effect of the Loa mutation in the function of the cytoplasmic dynein complex. Protein-protein interaction assays were performed on NIH3T3, NSC34 and HEK293T cells transfected with a 2 kb fragment of the wild type or mutant dynein heavy chain gene 1 bearing the Loa mutation and seven different intermediate chain isoforms. The results indicated a 2.5 fold increase in the binding affinity of the mutant dynein heavy chain 1 727 amino acid fragment for the dynein intermediate chain gene 2 isoform A, compared to the wild type.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available