Use this URL to cite or link to this record in EThOS: | https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.494884 |
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Title: | The role of n-linked glycosylation and sialylation in regulating human proteinase-activated receptor 1 and 4 expression and signalling | ||||||
Author: | Xiao, Yu Pei |
ISNI:
0000 0001 3573 7721
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Awarding Body: | University of Hull | ||||||
Current Institution: | University of Hull | ||||||
Date of Award: | 2008 | ||||||
Availability of Full Text: |
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Abstract: | |||||||
Proteinase-activated receptors (PARs) are a novel family of G-protein coupled receptors (GPCRs) that mediate many of the diverse biological effects of proteinases on target cells. N-linked glycosylation is a common post-translational modification in the GPCR superfamily that enables the cell to regulate protein function without recourse to the genome. Previous pharmacological studies have found that activation of hPAR-2 by mast cell tryptase can be regulated by receptor N-terminal glycosylation. However, the role of N-linked glycosylation in regulating the expression and function of other PARs is not known.
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Supervisor: | Compton, Steven J. ; Morice, Alyn H. | Sponsor: | Not available | ||||
Qualification Name: | Thesis (Ph.D.) | Qualification Level: | Doctoral | ||||
EThOS ID: | uk.bl.ethos.494884 | DOI: | Not available | ||||
Keywords: | Medicine | ||||||
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