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Title: The analytical chemistry of synthetic routes to psychoactive tryptamines
Author: Brandt, Simon D.
Awarding Body: University of Manchester
Current Institution: University of Manchester
Date of Award: 2004
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Many tryptamine derivatives are known to induce altered states of consciousness and the term 'hallucinogens' is commonly used for this type of compound in an attempt to describe their powerful impact on human perception, mood and cognition. These compounds increasingly of interest in forensic and neurobiological studies. The degree of alkylation of the side chain nitrogen in tryptamines is one important factor that affects psychoactivity. The method of Speeter and Anthony is considered to be one of the most important synthetic preparative methods. This synthetic route involves, acylation of a (substituted) indole with oxalyl chloride followed by reaction with an amine to give an indole-3-yl-glyoxalylamide. This amide is then reduced with lithium aluminium hydride to tryptamines.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available