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Title: Structural and functional studies on TDP-43, a novel splicing regulator
Author: D'Ambrogio, Andrea
ISNI:       0000 0001 3401 0854
Awarding Body: Open University
Current Institution: Open University
Date of Award: 2009
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TDP-43 is an RNA-binding protein with particular predilection for UG repeats that was shown to regulate transcription, to mediate mRNA stability and to inhibit splicing in the CFTR and Apo All genes.Recently, TDP-43 has been found to be the major disease protein in Amyotrophic Lateral Sclerosis (ALS) and Fronto-temporal Lobar dementia [ftld]. Objective of this thesis was to characterize the function of TDP-43 with in-vitro and in vivostudies.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available