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Title: Prostasomes : a role in prostatic disease?
Author: Stewart, Alistair Bryce
Awarding Body: University of Southampton
Current Institution: University of Southampton
Date of Award: 2007
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This thesis reports the start of work to identify whether or not prostasomes have a role in the aetiology or progression of benign and malignant prostate disease. The initiation of reliable isolation of prostasomes for use in future prostasome related research within the department is reported. Part of this process involved a review various biochemical and morphological properties. Anti-prostasome antibodies (APA) have been identified in serum of patients with prostate cancer and have been proposed as a new marker for metastatic disease. Due to the impact of this possibility a pilot study for APA in prostate cancer using an enzyme linked immunosorbent assay (ELISA) was performed. Anti-prostasome antibodies in varying amounts were present in healthy individuals and in men with prostate cancer. Higher levels were inversely and significantly associated with prostate specific antigen (PSA). Trends, but no significant relationship between APA levels and other parameters such as age, time since diagnosis, metastatic status, Gleason histological score and hormonal treatment were noted. The presence of APA does not appear, from this small series, to be a strong prognostic indicator for prostate cancer. However, the immune reactions to proteasomes are in any case of considerable interest both in the biology of prostate cancer and in the fertility context. Work initiated from this thesis continues in the department.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available