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Title: Multivariate mapping of G protein-coupled receptor ligand binding sites
Author: Evans, Philip James
ISNI:       0000 0001 3454 0468
Awarding Body: University of Portsmouth
Current Institution: University of Portsmouth
Date of Award: 2008
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G Protein-Coupled Receptors (GPCRs) are a class of membrane-bound receptors of considerable interest to the pharmaceutical industry, with greater than 25% of pharmaceutical research efforts directed toward the discovery of agonists or antagonists for these receptors. It is a considerable challenge in drug discovery to able to predict where a ligand will bind at a receptor and to determine the positions that describe how ligand-receptor selectivity occurs. Current research strategies are aimed towards homology modelling and literature evidence of binding mode in order to identify sites of ligand binding within GPCRs.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available