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Title: Molecular basis of bacterial-epithelial interaction in the gut
Author: Bannon, Ciara
ISNI:       0000 0001 3443 2889
Awarding Body: The University of Manchester
Current Institution: University of Manchester
Date of Award: 2008
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Flagellin which is expressed by both pathogenic and commensal bacteria in the gut is recognised as a key player in the regulation of gut immunity. Acting through toll-like receptor (TLR) 5, flagellin is highly antigenic and capable of activating pro inflammatory responses which if unregulated can lead to the development of chronic inflammatory disease. The gut epithelium represents the first point of contact between the enteric microflora and the innate immune system. The ability to control the epithelial response to flagellin is therefore crucial in determining whether this antigen will have beneficial homeostatic effects or promote inflammation. The objective of the present study is to identify and characterize potential mechanisms that activate or suppress flagellin responses in the human colonic epithehum.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available