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Title: The developmental origin and regulation of skeletal muscle stem cells
Author: Otto, Anthony Meekan
ISNI:       0000 0001 3461 1051
Awarding Body: The University of Reading
Current Institution: University of Reading
Date of Award: 2007
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Adult skeletal muscle harbours tissue specific stem cell population called satellite cells that are essential for postnatal muscle growth and repair. All satellite cells express the transcription factor Pax7 and a subset also expresses the homologous gene Pax3. Pax and Pax7 are also expressed in emerging embryonic muscle precursors. Recent studies have shown that satellite cells originate in the embryonic dermomyotome, however their developmental regulation throughout embryogenesis and the molecular control of their activation and proliferation in the adult remains unclear.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available