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Title: Abnormalities in heparan sulfate structure and epitope distribution in hypoplastic lungs from a teratogenic rat model of congenital diaphragmatic hernia : possible contribution to pathogenesis
Author: Thompson, Sophie Marie
ISNI:       0000 0001 3531 6409
Awarding Body: University of Liverpool
Current Institution: University of Liverpool
Date of Award: 2008
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The complex polysaccharide, heparan sulfate (HS), regulates airway development by controlling cell-cell and cell-matrix communication via interactions with a vast number of proteins e.g., growth factors. Loss of HS biosynthetic enzymes in Drosophila and mice illustrates the requirement for HS in airway morphogenesis and results in a major disruption in airway branching, and in the mouse, neonatal death. However, knowledge of HS structure within the lung is limited. HS antibodies produced by 'phage display provide a new tool for analysing HS in situ and have allowed specific HS structures to be probed in the lung.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral