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Title: Characterisation of the role and regulation of excreted proteins produced by Enterococcus facecalis
Author: Walker, Rachel Georgina
ISNI:       0000 0001 3556 0583
Awarding Body: University of Liverpool
Current Institution: University of Liverpool
Date of Award: 2008
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The commensal bacterium Enterococcus faecalis has emerged as an opportunistic pathogen capable of causing a range of infections. Little is known about the role and regulation of excreted proteins in E. faecalis virulence. Cytolysin is regulated via a specific density regulation mechanism and expression of GelE and SprE is dependent on the quorum sensing regulatory system FsrABCD. Fsr is predicted to be a global regulator of protein synthesis but it is not known whether there are multiple hierarchical regulators that modulate Fsr expression, as seen in the homologous Agr system in Staphylococcus aureus. This study sought lo investigate the variability and regulation of excreted proteins in the lab strains OGIRF and JH2-2 and in a set of diverse clinical isolates.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral