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Title: Development of methodologies for improvement in signal detection using prescription-event monitoring as a postmarketing surveillance platform
Author: Ferreira, Germano L. C.
ISNI:       0000 0001 3462 491X
Awarding Body: University of Portsmouth
Current Institution: University of Portsmouth
Date of Award: 2008
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The use of therapeutic drugs is associated with potential risks; therefore, public health surveillance systems have been developed to monitor the safety of medicines through a process of signal detection and assessment. Prescription-event monitoring (PEM) is one such active system, based on the study of cohorts of patients exposed to a recently licensed drug. As signal detection (SD) is a fundamental part of postmarketing surveillance, an understanding of factors influencing the performance of SD is paramount to plan and operate effective surveillance. This study aims to: characterize and evaluate the determinants that affect SD; design and pilot a systematic process, including SD methods and a work flow for planning and operating SD in PEM.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available