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Title: An in vitro and in vivo analysis of retinoid receptor-nucleosome interactions and chromatin remodelling
Author: Wiltshire, John Howard
ISNI:       0000 0001 3570 6415
Awarding Body: University of Portsmouth
Current Institution: University of Portsmouth
Date of Award: 2008
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DNA is compacted in the nucleus of eukaryotic cells into chromatin and the fundamental subunit is the nucleosome that consists of an octamer of histones surrounded by 1.67 superhelical turns of 146-147 bp DNA. Nucleosomes will therefore invariably affect the regulation of gene expression by restricting the access of regulatory proteins to DNA. The retinoid receptors are class II nuclear receptors that form heterodimers and bind to retinoic acid response elements (RAREs), found in the promoters of retinoid responsive genes.
Supervisor: Not available Sponsor: Not available
Qualification Name: Thesis (Ph.D.) Qualification Level: Doctoral
EThOS ID:  DOI: Not available